diabetes insipidus safety considerations

Diabetes may leave you prone to gum infections. Youll be asked to stop drinking water for a specified period of time before the water deprivation test. [1] Levy M, Prentice M, Wass J. Diabetes insipidus. Moreover, the occurrence of empty sella syndrome, as revealed on MRI scans, was highest in patients with deficits. Nail Products are products that are used to color the nails, to protect them against damage, to soften and condition cuticles, and to supplement the nails. Diabetes insipidus occurs when your body doesnt make enough antidiuretic hormone (ADH). Gestational diabetes insipidus is a rare, temporary condition that can develop during pregnancy. Diabetes insipidus is a condition caused by not enough antidiuretic hormone (ADH) in the body. Researchers havent found an effective way to treat dipsogenic diabetes insipidus. They may also feel thirsty all the time and drink lots of liquids, a condition called polydipsia. The customer service is impeccable. Secondary nephrogenic diabetes insipidus as a complication of inherited renal diseases. There is evidence for higher risk in those with diabetes undergoing surgery and, when such evidence is lacking, it may in part be testament to the relative safety of modern surgery and anaesthesia. Women who are pregnant with more than one baby are more likely to develop the condition because they have more placental tissue.3 Because the liver plays a role in curbing the enzyme that breaks down vasopressin, diseases and conditions that affect liverfunction also increase risk. Treatment for diabetes insipidus of nephrogenic origin involves using thiazide, diuretics, mild salt depletion, and prostaglandin inhibitors (eg., ibuprofen, indomethacin, and aspirin). WebDiabetes insipidus is seen most frequently in neurosurgical patients. ecacy and safety of desmopressin in patients with central diabetes insipidus. Desmopressin and indomethacin therapy for nephrogenic diabetes insipidus in patients receiving lithium carbonate. Considerations in choosing therapies include efficacy, cost, potential side effects, effects on weight, cormobidities, hypoglycemia risk, and patient preference. " />, Call Us: Miami (305) 649-5344 / CALL FREE: 800-910-8378 Hialeah Gardens (305) 822-0666 | info@cdltmds.com | My Account. When you need to get rid of water, ADH is either released in smaller amounts or not released at all, and youll urinate more often. Groovy Discord Bot Spotify, doi: 10.7759/cureus.13523. When your body needs to retain water, the pituitary gland will release ADH into the bloodstream. Seek care right away if you feel, The main symptoms of diabetes insipidus are, Diabetes insipidus is usually caused by problems with a hormonecalled vasopressin that helps your kidneys balance the amount of fluid in your body. WebThe management of central diabetes insipidus has been greatly simplified by the introduction of desmopressin (DDAVP). After the administration of ADH, the osmolality will rise to more than 750 mOsm/kg in central DI but will not rise at all in nephrogenic DI. "> Childs Nerv Syst. As a result, too much fluid gets flushed out in your urine. With almost curated, well priced and 100% genuine brands and products, Gawra prides itself for offering a comprehensive selection of makeup, skincare, hair care, fragrances, bath and body, luxury and wellness products for women and men. There is a lack of accepted safety for use under medical supervision. Diabetes insipidus (DI) is a rare condition that occurs when your kidneys are unable to conserve water. Drug-induced diabetes insipidus is always of the nephrogenic type, i.e. Other possible causes of the kidney damage and nephrogenic diabetes insipidus include: The kidneys are made up of small structures called nephrons. 2019 Aug 17. Also, I like the transparency about the brand, ingredients, and store openings. WebDiabetes insipidus, the inability to concentrate urine resulting in polyuria and polydipsia, can have different manifestations and management considerations in infants and This is a hormone that helps the kidneys keep the correct amount of water in the body. Diabetes insipidus is a rare but treatable chronic condition caused by the lack of the posterior pituitary hormone vasopressin (AVP, also known as anti-diuretic hormone) resulting in uncontrolled diuresis. [QxMD MEDLINE Link]. Diabetes is a disease of impaired carbohydrate metabolism that results from inadequate production or utilization of the hormone insulin. 21(4):122-9; quiz 129. [QxMD MEDLINE Link]. Kim RJ, Malattia C, Allen M, Moshang T, Maghnie M. Pediatr Endocrinol Rev, 2 Suppl 1:115-123, 01 Nov 2004 Cited by: 10 articles | PMID: 16456490. Review Diabetes insipidus can be temporary or permanent. Approach Considerations. J Nephrol. Jagdeesh Ullal, MD, MS, FACE, FACP, ECNU is a member of the following medical societies: American Medical Association, International Society for Clinical Densitometry, Medical Society of VirginiaDisclosure: Nothing to disclose. Diabetes insipidus (DI) is characterized by the decreased ability of the kidneys to concentrate urine. Always talk with your health care provider before you participate in a clinical study. J Am Coll Surg. [QxMD MEDLINE Link]. The ADH test measures how much ADH is in your, Drug manufacturer Eli Lilly announced yesterday that its implementing multiple price-lowering changes that will reduce out-of-pocket costs for, Researchers say people who follow eight recommended lifestyle habits tend to live longer and without diseases such as type 2 diabetes, cancer, and, Twenty minutes of exercise a day can help keep people with a variety of health conditions out of the hospital, according to new research. Passport Request After Biometrics, Polydipsia. It is treated with desmopressin (DDAVP, a synthetic AVP analogue) which reduces diuresis. Diabetes insipidus. If you're feeling very thirsty at night, it could be due to a number of different reasons, some more serious than others. 12 hours of water deprivation) or by administration of a modified antidiuretic hormone, desmopressin, to demonstrate the renal unresponsiveness. Nursing Interventions Skin Care Assess/monitor skin turgor and mucous membranes. This is known as a urine specific gravity test. Diabetes is a group of conditions linked by an inability to produce enough insulin and/or to respond to insulin. Macalester College Financial Aid For International Students, Diabetes insipidus is a condition caused by not enough antidiuretic hormone (ADH) in the body. determinations are not available, a single cPPG level >150 mg/dl may be used during a clinic visit to identify most inadequately controlled patients and allow timely intensification of therapy.. --> However, nephrogenic diabetes insipidus takes 24 days to come about, does not occur in all patients receiving these agents, may be associated with renal toxicity (in the case of lithium), and corrects hyponatremia rather slowly by 24 mmol/liter/day [Forrest et al. 2023 Jan;45(1):94-95. doi: 10.1177/02537176221109962. [33]. New England Journal of Medicine. J Clin Invest. Autosomal dominant neurohypophyseal diabetes insipidus in two families. Bockenhauer D, van't Hoff W, Dattani M, Lehnhardt A, Subtirelu M, Hildebrandt F, et al. While most people make 1 to 3 quarts of urine a day, people with diabetes insipidus can make up to 20 quarts of urine a day. Hattiesburg Impact Classifieds, How do health care professionals treat diabetes insipidus? Pratheesh R, Swallow DM, Rajaratnam S, Jacob KS, Chacko G, Joseph M, et al. 2022 Jan;28(1):205-210. doi: 10.1177/10781552211013878. Gawra has its origin in India with corporate offices in Saudi Arabia. Diabetes insipidus (DI) is a rare condition that occurs when your kidneys are unable to conserve water. government site. Aquaporins in clinical medicine. Problems with a part of your brain that controls thirst can also cause diabetes insipidus. Mol Pharmacol. ADH is also known as vasopressin. Diabetes insipidus is a condition caused by not enough antidiuretic hormone (ADH) in the body. we are the market leader in more than half. WebDiabetes insipidus occurs when your body doesnt make enough antidiuretic hormone (ADH). They include nail polish and enamels and nail polish and enamel removers. This condition is easily diagnosed by In central and nephrogenic DI, urinary osmolality will be less than 300 mOsm/kg after water deprivation. Your health care professional may also prescribe a class of diuretic medicines called thiazides to help reduce the amount of urine your kidneys make.2,7 Other treatments can include nonsteroidal anti-inflammatory drugsor other types of diuretics. Permanent DI is seen in patients with extensive damage in the hypothalamic area. While taking this medication, its important to regulate your water intake and drink only when youre thirsty. People with this disorder need to urinatefrequently, called polyuria. Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, Endocrine SocietyDisclosure: Nothing to disclose. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. The management of central diabetes insipidus has been greatly simplified by the introduction of desmopressin (DDAVP). What is Diabetes? Bendamustine-induced nephrogenic diabetes insipidus - A case report. Learn more about this rare disease that causes you to urinate often. In healthy individuals, water deprivation leads to a urinary osmolality that is 2-4 times greater than plasma osmolality. Specific causes vary among the four types of diabetes insipidus: central, nephrogenic, dipsogenic, and gestational.2. Patients may experience reversible diabetes insipidus, manifested by the development of polyuria, a dilute urine, and hypernatremia, after cessation of treatment with vasopressin. Your doctor will also look closely at images of your hypothalamus or pituitary gland for any damage or abnormalities. Dose reduction is needed in patients with renal impairment. There are few cases reporting chlorothiazide as a temporizing measure for central diabetes Magnesium ADH is also known as vasopressin. It is a rare disease that causes you to urinate often. Krahulik D, Zapletalova J, Frysak Z, Vaverka M. Dysfunction of hypothalamic-hypophysial axis after traumatic brain injury in adults. This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases Diabetes insipidus--diagnosis and management. Federal government websites often end in .gov or .mil. Babey M, Kopp P, Robertson GL. Society for Endocrinology clinical guidance: inpatient management of cranial diabetes insipidus. 2010 Apr. Mac Windowserver High Memory, Fluid status should be assessed regularly, including monitoring of fluid input and urine output. 11(4):391-401. MeSH The extent of deprivation is usually limited by the patients thirst or by any significant drop in blood pressure or related clinical manifestation of dehydration. 298(6665):2-3. If you have diabetes insipidus and dont drink enough fluid to replace water loss through urine, you can become dehydrated, which is dangerous to your health. Because of this, diabetes insipidus is a serious condition that requires medical treatment. Cleveland Clinic is a non-profit academic medical center. In some cases, these changes alone may be enough to keep your symptoms under control, particularly if you have nephrogenic diabetes insipidus.2,7. Drug-induced nephrogenic diabetes insipidus is not a common disorder except in patients receiving treatment with lithium salts for affective disorders where it may affect about 10% of patients treated long term (15 years). Maternal Considerations: There are no adequate reports or well-controlled studies of demeclocycline during pregnancy. Gilman A, Goodman L. The secretory response of the posterior pituitary to the need for water conservation. When you volunteer to take part in a clinical study, you help doctors and researchers learn more about disease and improve health care for people in the future. WebIntravenous fluids Dehydration Key points Children with suspected or known diabetes insipidus (DI) must always have free access to water. Diabetes Insipidus Induced by Oral Olanzapine at Therapeutic Dose. Clipboard, Search History, and several other advanced features are temporarily unavailable. Damage to the pituitary gland can be caused by different diseases as well as by head injuries, neurosurgery, or genetic disorders. [QxMD MEDLINE Link]. Patients with diabetes insipidus who have a functioning thirst mechanism and are able to maintain their fluid intake through drinking should be identified on admission and allowed to continue their normal prescribed desmopressin/DDAVP. 22(5):393-9. Planet Fitness Revere, Ma Hours, [QxMD MEDLINE Link]. Moreover, postoperative hemorrhage was found to be associated with permanent DI. Andereggen L, Hess B, Andres R, et al. Groovy Discord Bot Spotify, The low sodium diet is prescribed by a physician and is one component of effective treatment for NDI. Epub 2022 Jul 15. Diabetes insipidus. [QxMD MEDLINE Link]. Read this chapter of Quick Medical Diagnosis & Treatment 2020 online now, exclusively on AccessMedicine. 71(2):111-9. With mild polyuria, water deprivation can begin the night before the test. When 2 sequential urinary osmolalities vary by less than 30 mOsm/kg or when the weight decreases by more than 3%, 5 U of aqueous ADH or desmopressin are administered subcutaneously. Kumar MP, Ramamurthy P, Solomon S, Raj P. Indian J Psychol Med. Diabetes insipidus is rare, affecting about 1 in 25,000 people worldwide.1, People of all ages can develop diabetes insipidus. Other treatments vary by cause. When taking these medications, its important to drink water only when youre thirsty. Though the exact prevalence is unknown, Arthus et al. This website also contains material copyrighted by 3rd parties. Curr Drug Saf. The condition is also called water diabetes. The common clinical manifestation of the two subtypes is polyuria. If you wake up many times at night to urinate, your health care professional may suggest you take a small dose of desmopressin at bedtime. A search of the World Health Organization's adverse effect database revealed 359 reports of drug-induced diabetes insipidus. Mac Windowserver High Memory, The NIDDK conducts and supports clinical trials in many diseases and conditions, including kidney diseases. Potential of nonpeptide (ant)agonists to rescue vasopressin V2 receptor mutants for the treatment of X-linked nephrogenic diabetes insipidus. Your health care professional may also monitor your blood levels of sodium, which can drop too low if you have this condition. Learn more about this rare disease that causes you to urinate often. How do health care professionals diagnose diabetes insipidus? 2012. considerations. Today Gawra ships across the length and breadth of the country to almost every zip code using the services of leading and reliable courier companies. It makes less urine when you need to replace fluid lost to sweating and makes more urine when theres too much fluid in your body. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Ananthakrishnan S. Diabetes insipidus during pregnancy. Treating it often requires more than just drinking water , Antidiuretic hormone (ADH) is a hormone that helps your kidneys manage the amount of water in your body. But if your body cant make enough vasopressin, the fluid may get flushed out in your urine instead. Passport Request After Biometrics, Nephrogenic diabetes insipidus. Google Classroom Self Grading, Babylon 5 Phoenix Rising, 2018 Jan 30. Desmopressin may be prescribed for severe gestational diabetes insipidus. Verkman AS. J Pediatr. Hattiesburg Impact Classifieds, 2010 Nov-Dec. 23 Suppl 16:S43-8. Dipsogenic diabetes insipidus has also been associated with certain medications and conditions, including mental health conditions. 8600 Rockville Pike official website and that any information you provide is encrypted A healthy adult will typically urinate between 1 and 3 quarts (946.4 milliliters to 2.84 liters) of urine a day. The transient form is more common and usually subsides prior to discharge. Pituitary. Diabetes insipidus occurs when your body doesnt make enough antidiuretic hormone (ADH), or your kidneys don't react to it. -, J Affect Disord. 77(5):836-45. Diabetes insipidus is not the same as diabetes mellitus. WebDiabetes insipidus occurs when your body doesnt make enough antidiuretic hormone (ADH). 2022 Oct;36(10):1049-1077. doi: 10.1007/s40263-022-00952-y. Symptoms of diabetes insipidus. Find out about the causes and, Clear urine describes urine that doesnt have any sediment or cloudiness. Share cases and questions with Physicians on Medscape consult. Approach Considerations Fluid replacement Most patients with diabetes insipidus (DI) can drink enough fluid to replace their urine losses. doi: 10.1111/tog.12450, [4] Fenske W, Refardt J, Chifu I, et al. Heart Healthy Lifestyle Linked to Longer Life Without Type 2 Diabetes, Cancer, and Other Conditions, Studies Find 11 to 20 Minutes of Daily Exercise Might Lower Your Risk of Stroke, Heart Disease and Cancer, Diabetic Neuropathy: How Spinal Cord Stimulation May Help Relieve the Pain, Type 2 Diabetes: Why Many People Who Are Eligible Aren't Getting Treatments Such as Ozempic, excessive urine volume, which can cause you to, unusually wet diapers, bedwetting, or excessive urine output. 30 (2):305-15. 2008. This damage means ADH cannot be produced, stored, or released normally. Urinating, breathing, and sweating help eliminate fluid from your body. George T Griffing, MD Professor Emeritus of Medicine, St Louis University School of Medicine The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The condition is also called water diabetes. Treats Diabetes Insipidus: Hydrochlorothiazide is a diuretic, so it is highly effective in treating diabetes insipidus, a rare type of diabetes resulting due to the deficiency of pituitary hormone vasopressin that controls kidney functioning . Sucking on ice chips or sugar free candies to moisten your mouth and increase saliva flow may help reduce your thirst. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. The expected range for urine specific gravity is 1.010 - 1.025. Other tests and procedures may include. WebDiabetes insipidus is a rare but treatable chronic condition caused by the lack of the posterior pituitary hormone vasopressin (AVP, also known as anti-diuretic hormone) How do eating, diet, and nutrition affect diabetes insipidus? The time required to achieve maximal urinary concentration ranges from 4-18 hours. and transmitted securely. It has the following 2 major forms: Central Dosing: Adult. Macalester College Financial Aid For International Students, [QxMD MEDLINE Link]. Mutter CM, Smith T, Menze O, Zakharia M, Nguyen H. Cureus. 2011 Jul 5. Diagnosis and the tests for Diabetes Insipidus are done in a health setting under the request and guidance of qualified medical personnel.. Every day, our kidneys filter 120 to 150 quarts of blood and play a role to maintain fluid balance in our bodies. Characterized by the passage of large amounts of dilute urine, increased thirst, and an increased likelihood of dehydration, this disorder is seen across the lifespan, equally among men and women. Causes include, In this type of diabetes insipidus, a problem with your hypothalamus causes you to feel thirsty and drink more liquids. Type 2 diabetes: Symptoms. Do not stop taking any medication without talking with your doctor first. Never restrict fluid intake Urine In some cases, nephrogenic diabetes insipidus may go away after treating its cause. The condition is also called water diabetes. 1 About half of the patients who receive this drug have some degree of impaired renal urinary concentration capacity and about 20% develop symptomatic nephrogenic diabetes insipidus. Babylon 5 Phoenix Rising, Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts. Rochdi MD, Vargas GA, Carpentier E, Oligny-Longpr G, et al. 2000 Apr. 7:550. 1997 May 1;55(6):2146-53. Bookshelf The result of this test must be interpreted with caution, however, because patients with partial nephrogenic DI or primary polydipsia may show a response similar to that seen in central DI. ADH levels affect how well your kidneys conserve water. This is a hormone that helps the kidneys keep the correct amount of water in the body. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE3NjQ4LXdvcmt1cA==. This condition is easily diagnosed by measuring urinary concentrating capacity during a thirst test (e.g. 1985 Aug. 103(2):228-39. People with diabetes insipidus often feel thirsty all the time and drink lots of liquids. Hannon MJ, Sherlock M, Thompson CJ. [QxMD MEDLINE Link]. 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Polyuria of 4 to 24 L per day. It is a rare disease that causes you to urinate often. Moreover, as your blood sugar levels increase, additional problems such as headaches, blurred vision, and fatigue the 1 last update 26 May 2021 will occur.Symptoms include dry mouth, bigger appetite, frequent urination, and unusual weight loss or gain. Babylon 5 Phoenix Rising, 1997 Apr;43(2):151-61 This site needs JavaScript to work properly. Desmopressin acetate injection 4 mcg/mL is indicated as antidiuretic replacement therapy in the management of central (cranial) diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. Incidence, predictors and early post-operative course of diabetes insipidus in paediatric craniopharygioma: a comparison with adults. Replacement fluids should be given orally or nasogastrically as quickly as is clinically safe to minimise the risk of rapid changes in serum sodium. With severe polyuria, water restriction is carried out during the day to allow close observation. Traumatic brain injury (TBI) is a significant cause of morbidity and mortality in many age groups. Gestational diabetes is a type of diabetes that is first seen in a pregnant woman who did not have diabetes before she was pregnant. [QxMD MEDLINE Link]. Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference, Frederick H Ziel, MD Associate Professor of Medicine, University of California, Los Angeles, David Geffen School of Medicine; Physician-In-Charge, Endocrinology/Diabetes Center, Director of Medical Education, Kaiser Permanente Woodland Hills; Chair of Endocrinology, Co-Chair of Diabetes Complete Care Program, Southern California Permanente Medical Group, Frederick H Ziel, MD is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Endocrinology, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Diabetes Association, American Federation for Medical Research, American Medical Association, American Society for Bone and Mineral Research, California Medical Association, Endocrine Society, andInternational Society for Clinical Densitometry. Your doctor will take a sample of your urine to test for salt and other waste concentrations. Gawra has its origin in India with corporate offices in Saudi Arabia.We offer a wide range of high-quality beauty products as well as a unique opportunity to join our sales force and start your own business. 1. A urinary osmolality that is 300-750 mOsm/kg after water deprivation and remains below 750 mOsm/kg after administration of ADH may be seen in partial central DI, partial nephrogenic DI, and primary polydipsia. J Physiol. Updated 2020 Feb 27. Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus. Monitor serum electrolytes, fluid status, and urine output after vasopressin discontinuation. Patients with diabetes insipidus who do not have a functioning thirst mechanism or are unable to maintain their fluid intake through drinking (due to disability, reduced consciousness or primary pathology) should be identified on admission and provided with the agreed, prescribed dose of desmopressin/DDAVP. [QxMD MEDLINE Link]. It is too soon to know if supplementation helps with diabetes. Perform testing with the patient maximally dehydrated as toleratedthat is, at a time when ADH release is the highest and his/her urine is the most concentrated. See Important Safety, Prescribing Information & Medication Guide on site. Hansen LK, Rittig S, Robertson GL. 2008 Oct. 207(4):477-84. GeneReviews. Nat Rev Endocrinol. Resveratrol is a chemical found in wine and grapes. 2018 Feb 14. Your health care professional may refer you to a specialist, such as a nephrologistor an endocrinologistfor more specific treatments. Gawra is a leading beauty company selling direct. 2008 Dec. 217(3):605-17. If they receive intravenous fluid therapy serum sodium levels should be monitored at least every 24 hours in case hyponatraemia occurs. Gawra products are globally acclaimed and are available at attractive price points in all its markets from Saudi Arabia. Disclaimer. Most people with diabetes insipidus can prevent serious problems and live a normal life if they follow their health care professionals recommendations and keep their symptoms under control. The hormone signals your kidneys to conserve fluids by pulling fluids from your urine and returning fluid to your bloodstream. Diabetes insipidus during pregnancy: perinatal and postpartum considerations. It occurs in approximately 1 in 25,000 people, and can affect anyone of any age, although it is more common in adults. People with this disorder need to WebDrug-induced diabetes insipidus is always of the nephrogenic type, i.e. In the absence of appropriate management, permanent renal damage When animals were provided free access to water, no antidiuretic activity was recovered from urine, and no antidiuretic activity could be recovered from the urine of hypophysectomized rats dehydrated with hypertonic saline. The main complication of diabetes insipidus is dehydration, which happens when your body loses too much fluid and electrolytesto work properly. An expectant mothers placenta does not destroy desmopressin as it does vasopressin. Diabetes insipidus: A matter of fluids. Molecular biology of hereditary diabetes insipidus. FOIA Replacement fluids should be given orally or nasogastrically as quickly as is clinically safe to minimise the risk of rapid changes in serum sodium. Allen HM, Jackson RL, Winchester MD, Deck LV, Allon M. South Med J. 2010 May. These drugs are not currently used very often to correct hyponatremia. Planet Fitness Revere, Ma Hours, Diabetes mellitus gets its name from the fact that a primary symptom of diabetes is sweet-smelling urine. Among U.S. seniorspeople aged 65 years and older11.8 million people, or 25 percent, have diabetes, according to the American Diabetes Association.November is National Diabetes Month, a time to become more knowledgeable about this increasingly common disease and how massage can help people who have diabetes. A prospective study by Winzeler et al indicated that measurement of plasma copeptin at baseline and following arginine stimulationmay bean effective means of differentiating DI from primary polydipsia. Please enable it to take advantage of the complete set of features!

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diabetes insipidus safety considerations

diabetes insipidus safety considerations